The temporary use of an adulticide product may be necessary to kill these adult fleas. These adult fleas are unable to produce viable offspring. If a SENTINEL FLAVOR TABS-treated dog comes in contact with a flea-infested environment, adult fleas may infest the treated animal. The concurrent use of an approved adulticide may be employed depending on the severity of the infestation. Cooler geographic areas may have longer lag periods due to a prolonged flea life cycle. Therefore, noticeable control may not be observed until several weeks after dosing when a preexisting infestation is present. Based on results of clinical studies, this emergence generally occurs during the first 30-60 days. However, preexisting flea populations may continue to develop and emerge after treatment with SENTINEL FLAVOR TABS has begun. SENTINEL FLAVOR TABS immediately break the flea life cycle by inhibiting egg development.

These reactions are presumably caused by release of protein from dead or dying microfilariae. Mild, transient hypersensitivity reactions manifested as labored respiration, vomiting, salivation and lethargy have been noted in some treated dogs carrying a high number of circulating microfilariae. Infected dogs should be treated to remove adult heartworms and microfilariae prior to initiating treatment with SENTINEL FLAVOR TABS. Prior to administration of SENTINEL FLAVOR TABS, dogs should be tested for existing heartworm infections. Precautionsĭo not use in puppies less than four weeks of age and less than two pounds of body weight. Without concurrent use of an adulticide, adequate flea control may not be achieved in dogs that have repeated exposure to flea infested animals or environments. Concurrent use of an adulticide product may be necessary for adequate control of adult fleas. Lufenuron controls flea populations by preventing the development of flea eggs and does not kill adult fleas. SENTINEL FLAVOR TABS are also indicated for the prevention of heartworm disease caused by Dirofilaria immitis, for the prevention and control of flea populations, the control of adult Ancylostoma caninum (hookworm), and the removal and control of adult Toxocara canis and Toxascaris leonina (roundworm) and Trichuris vulpis (whipworm) infections. SENTINEL FLAVOR TABS are indicated for use in dogs and puppies, four weeks of age and older, and two pounds body weight or greater. Lufenuron prevents most flea eggs from hatching or maturing into adults and thus prevents and controls flea populations by breaking the life cycle. After biting a lufenuron-treated dog, the female flea ingests a blood meal containing lufenuron which is subsequently deposited in her eggs. Lufenuron has no effect on the adult flea. Lufenuron’s mode of action is interference with chitin synthesis, polymerization and deposition. Lufenuron, the other active ingredient in SENTINEL FLAVOR TABS, is an insect development inhibitor which breaks the flea life cycle by inhibiting egg development. Milbemycin oxime eliminates the tissue stage of heartworm larvae and the adult stage of hookworm (Ancylostoma caninum), roundworm (Toxocara canis and Toxascaris leonina) and whipworm (Trichuris vulpis) infestations when administered orally according to the recommended dosage schedule. Milbemycin oxime, one active ingredient in SENTINEL FLAVOR TABS, is a macrocyclic anthelmintic which is believed to act by interfering with invertebrate neurotransmission. Benzoylphenylurea compounds, including lufenuron, are classified as insect development inhibitors (IDIs). Lufenuron is a benzoylphenylurea derivative with the following chemical composition: N-2,6-difluorobenzamide (C 17H 8Cl 2F 8N 2O 3, MW 511.15). Milbemycin oxime is classified as a macrocyclic anthelmintic.

Milbemycin oxime consists of the oxime derivatives of 5-didehydromilbemycins in the ratio of approximately 80% A 4 (C 32H 45NO 7, MW 555.71) and 20% A 3 (C 31H 43NO 7, MW 541.68). Each tablet is formulated to provide a minimum of 0.23 mg/pound (0.5 mg/kg) of milbemycin oxime and 4.55 mg/pound (10 mg/kg) body weight of lufenuron. SENTINEL FLAVOR TABS are available in four tablet sizes in color-coded packages for oral administration to dogs and puppies according to their weight. Keep this and all drugs out of the reach of children. Sentinel Flavor Tabs Cautionįederal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. SENTINEL ® FLAVOR TABS ® (milbemycin oxime/lufenuron) also control flea populations and adult hookworms, and remove and control adult roundworm and whipworm infections in dogs and puppies. The palatable once-a-month prescription tablet that prevents heartworm disease and flea populations in dogs and puppies.

Sentinel heartworm ingredients